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ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune Evasion

2025-07-21

Abstract excerpt

Transcriptional Intratumoral heterogeneity (ITH) is a hallmark of aggressive cancers, yet how transcriptional ITH programs drive tumor metastasis and immune evasion in upper aerodigestive squamous cell carcinoma (UASCC) remains unclear. Through single-cell RNA sequencing analysis of UASCC cells and patient tumors, we uncovered a hybrid epithelial mesenchymal transition (hEMT) ITH program linked to metastatic disse...

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Identifiers and source

Literature Corpus work
c01bdddf-68a2-54b6-b553-aedb725fe196
DOI
10.1101/2025.07.17.665404
Open publication

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ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune EvasionDOI 10.1101/2025.07.17.665404
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