Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis

4 Feb 2025

Abstract excerpt

BACKGROUND: Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity in Esophageal Squamous Cell Carcinoma (ESCC). Examining the chromatin accessibility of ESCC at single-cell level is imperative to understand how it activates oncogenes and contributes to the onset and metastasis of ESCC. METHODS: We performed single-cell assay for transposase-accessible chromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Immune cells in cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39905485
DOI: 10.1186/s12967-025-06154-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysisPMID 39905485Read ↗

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinomaSemantic proximity Read ↗

Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinomaSemantic proximity Read ↗

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinomaSemantic proximity Read ↗

Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Multi-omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma.Semantic proximity Read ↗

Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in oesophageal squamous cell carcinomaSemantic proximity Read ↗

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysisSemantic proximity Read ↗

Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in esophageal squamous cell carcinomaSemantic proximity Read ↗

ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune EvasionSemantic proximity Read ↗

Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinomaSemantic proximity Read ↗

Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinomaSemantic proximity Read ↗

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.