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Article

A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer.

Theranostics - 1 Jan 2026

Yan Yueren, Shang Jun, Liu Chunnan, Chen Yuting, Bao Yufang, Zhao Yue, Fan Fanfan, Sun Yifu, Zhou Yudi, Wu Yuke, Wang Yongbo, Han Han, Chen Haiquan, Pan Yunjian

Abstract excerpt

Background: Epidermal growth factor receptor (EGFR) mutations occur frequently in lung adenocarcinoma (LUAD). However, the lack of practical preclinical models has limited our understanding of how EGFR mutations reshape the tumor immune microenvironment. Methods: EGFRE19del/E19del; Trp53-/- (EP) cell lines were established from a human EGFR exon 19 deletion mutated genetically engineered mouse model (GEMM). These...

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Identifiers

PMID: 41356800
DOI: 10.7150/thno.118234
PMCID: PMC12675003

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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