Back to search

Article

Mutual Inhibition Model of pattern formation: The role of Wnt-Dickkopf interactions in driving <i>Hydra</i> body axis formation

2021-09-13

Abstract excerpt

The antagonistic interplay between canonical Wnt signalling and Dickkopf (Dkk) proteins is fundamental to tissue organisation, including stem cell differentiation and body-axis formation. Disruptions in this interaction are linked to various human diseases, yet the mechanisms enabling robust body-axis formation through β -catenin/Wnt–Dkk interactions remain unclear. A key model system for Wnt-driven pattern forma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c01ae4b6-b9b8-587d-94ed-7da2271ec5b3
DOI
10.1101/2021.09.13.460125
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mutual Inhibition Model of pattern formation: The role of Wnt-Dickkopf interactions in driving <i>Hydra</i> body axis formationDOI 10.1101/2021.09.13.460125
Wnt3 expression as a readout of tissue stretching during <i>Hydra</i> regenerationSemantic proximity
Self-organization of a human organizer by combined Wnt and Nodal signallingSemantic proximity
Boundary constraints can determine pattern emergenceSemantic proximity
Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Semantic proximity
Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signalingSemantic proximity
Pattern formation by dynamically interacting network motifs.Semantic proximity
Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism.Semantic proximity
The feedback regulator Nord controls Dpp/BMP signaling via extracellular interaction with Dally in the <i>Drosophila</i> wingSemantic proximity
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.Semantic proximity
A wave of WNT signalling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cellsSemantic proximity
The <i>Wnt/β-catenin/TCF/Sp5/Zic4</i> gene network that regulates head organizer activity in <i>Hydra</i> is differentially regulated in epidermis and gastrodermisSemantic proximity
Formation of the BMP activity gradient in the Drosophila embryo.Semantic proximity
Select a neighboring publication to make it the new centre.