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The <i>Wnt/β-catenin/TCF/Sp5/Zic4</i> gene network that regulates head organizer activity in <i>Hydra</i> is differentially regulated in epidermis and gastrodermis

2024-04-29

Abstract excerpt

In Hydra , head formation depends on Wnt/β-catenin signaling, which positively regulates Sp5 and Zic4 , with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter drives eGFP expression in the epidermis or gastrodermis, we show that in intact animals, epidermal HySp5: GFP is expressed strongly apically and weakly along the body colum...

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Literature Corpus work
bd38c759-dd50-5c6d-95fb-57ba016b499c
DOI
10.1101/2024.04.27.591423
Open publication

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