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Article

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.

Developmental cell - 26 Sept 2016

Loh Kyle M, van Amerongen Renée, Nusse Roel

Abstract excerpt

There were multiple prerequisites to the evolution of multicellular animal life, including the generation of multiple cell fates ("cellular diversity") and their patterned spatial arrangement ("spatial form"). Wnt proteins operate as primordial symmetry-breaking signals. By virtue of their short-range nature and their capacity to activate both lineage-specifying and cell-polarizing intracellular signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27676437
DOI: 10.1016/j.devcel.2016.08.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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