Article

Inositol hexakisphosphate Functions as a Cofactor and Modulator of ADAR1 Activity

2026-01-18

Abstract excerpt

Adenosine-to-inosine (A-to-I) RNA editing by ADAR1 is a key post-transcriptional modification, and mutations in ADAR1 lead to Aicardi–Goutières syndrome (AGS), an autoimmune disorder. Despite its biological and clinical relevance, the regulation of ADAR1 activity remains incompletely understood. Using a combination of biochemical approaches, inositol-pentakisphosphate 2-kinase (IPPK)-knockout cells, molecular dyna...

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Literature Corpus work: c01a6495-b94a-5b8d-98f6-9aa92d664f97
DOI: 10.64898/2026.01.17.699700

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