Article

Ciliogenesis associated kinase 1 accumulates in its inactive form during polycystic kidney disease progression

2026-05-14

Abstract excerpt

Ciliogenesis associated kinase 1 (CILK1) deficiency in human and mice results in kidney developmental defects including cystogenesis. However, the biology of CILK1 in autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, remains to be investigated. Here, we show that CILK1 is overexpressed in dedifferentiated cells of renal tissue from ADPKD human patients in comparison t...

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Literature Corpus work: c0140d4b-3ae5-597e-b5ff-f97a640791e4
DOI: 10.64898/2026.05.13.724873

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