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Article

Acute kidney injury induces hallmarks of polycystic kidney disease

4 Aug 2016

Abstract excerpt

Acute kidney injury (AKI) and autosomal dominant polycystic kidney disease (ADPKD) are considered separate entities that both frequently cause renal failure. Since ADPKD appears to depend on a polycystin-1 (Pc1) or Pc2 dosage mechanism, we investigated whether slow progression of cystogenesis in two Pkd1 transgenic mouse models can be accelerated with moderate ischemia-reperfusion injury (IRI). Transient...

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PMID: 27488998
DOI: 10.1152/ajprenal.00167.2016

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