Article
The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts.
Nucleic acids research - 1 Sept 2009
Nakken Sigve, Rognes Torbjørn, Hovig Eivind
Abstract excerpt
Specific guanine-rich sequence motifs in the human genome have considerable potential to form four-stranded structures known as G-quadruplexes or G4 DNA. The enrichment of these motifs in key chromosomal regions has suggested a functional role for the G-quadruplex structure in genomic regulation. In this work, we have examined the spectrum of nucleotide substitutions in G4 motifs, and related this spectrum to G4...
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