Article

Evolutionary Dynamics of G-Quadruplexes in Human and Other Great Ape Telomere-to-Telomere Genomes

2024-11-06

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplexes (G4s) are non-canonical DNA structures that can form at approximately 1% of the human genome. G4s contribute to point mutations and structural variation and thus facilitate genomic instability. They play important roles in regulating replication, transcription, and telomere maintenance, and some of them evolve under purifying selection. Nevertheless, the evolutionary dynamics of G...

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Literature Corpus work: 918d17c6-8967-5a68-beb8-12d204c37202
DOI: 10.1101/2024.11.05.621973

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