Article

SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells

2024-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Cancer initiation and progression result from both genetic alterations and epigenetic reprograming caused by environmental or endogenous factors which can lead to aberrant cell signalling. Most colorectal cancers (CRC) are linked to the abnormal activation of the Wnt/ β-catenin pathway, whose key feature is the accumulation of acetylated β-catenin protein within the nucleus of colon epithelial c...

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Literature Corpus work: bf96b278-b818-5bbe-89d3-58e1ff136cf3
DOI: 10.1101/2024.01.21.576539

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