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Article

Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells.

Molecular carcinogenesis - 1 Apr 2010

Egan Jan B, Thompson Patricia A, Vitanov Milen V, Bartik Leonid, Jacobs Elizabeth T, Haussler Mark R, Gerner Eugene W, Jurutka Peter W

Abstract excerpt

The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon. We investigated the effect of a common FokI restriction si...

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Identifiers

PMID: 20043299
DOI: 10.1002/mc.20603
PMCID: PMC3074190

Genes

VDR
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20043299-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells.PMID 20043299Read ↗

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