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Article

Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer.

PloS one - 1 Jan 2011

Larriba María Jesús, Ordóñez-Morán Paloma, Chicote Irene, Martín-Fernández Génesis, Puig Isabel, Muñoz Alberto, Pálmer Héctor G

Abstract excerpt

Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and the induction of its target genes. Apc(min/+) mice are the most commonly used model for colon cancer. They harb...

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Identifiers

PMID: 21858154
DOI: 10.1371/journal.pone.0023524
PMCID: PMC3156234

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21858154-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer.PMID 21858154Read ↗

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