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Article

Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

21 Oct 2013

Abstract excerpt

The Wnt/b-catenin signaling pathway is abnormally activated in most colorectal cancers and in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis by regulating the expression of a large number of genes in tumor cells. The active vitamin D metabolite 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits Wnt/b-catenin signaling by several mechanisms at different points along the...

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PMID: 24202444
DOI: 10.3390/cancers5041242

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