Article
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
The Journal of cell biology - 23 Jul 2001
Pálmer H G, González-Sancho J M, Espada J, Berciano M T, Puig I, Baulida J, Quintanilla M, Cano A, de Herreros A G, Lafarga M, Muñoz A
Abstract excerpt
The beta-catenin signaling pathway is deregulated in nearly all colon cancers. Nonhypercalcemic vitamin D3 (1alpha,25-dehydroxyvitamin D(3)) analogues are candidate drugs to treat this neoplasia. We show that these compounds promote the differentiation of human colon carcinoma SW480 cells expressing vitamin D receptors (VDRs) (SW480-ADH) but not that of a malignant subline (SW480-R) or metastasic derivative...
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