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Article

SIRT1: a novel regulator in colorectal cancer

25 Jul 2024

Abstract excerpt

The class-III histone deacetylase SIRT1 is the most extensively investigated sirtuin deacetylase. It is resistant to the broad deacetylase inhibitor trichostatin A and depends on oxidized nicotinamide adenine nucleotide (NAD+). SIRT1 plays a crucial role in the tumorigenesis of numerous types of cancers, including colorectal cancer (CRC). Accumulating evidence indicates that SIRT1 is a therapeutic target for CRC;...

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PMID: 39059350
DOI: 10.1016/j.biopha.2024.117176

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