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Article

The Role of Vitamin D and Vitamin D Receptors in Colon Cancer

1 Jun 2017

Abstract excerpt

Epidemiological studies have demonstrated that vitamin D deficiency is associated with various human cancers. Vitamin D receptor (VDR) regulates most of the biological actions of the active vitamin D metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). VDR is highly expressed in small intestine and colon and has critical regulatory actions for proliferation and differentiation, intestinal barrier function, innate...

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PMID: 28662021
DOI: 10.1038/ctg.2017.31

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