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Article

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

15 Apr 2008

Abstract excerpt

Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health...

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PMID: 18414679
DOI: 10.1371/journal.pone.0002020

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