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Article

Doublecortin is required in mice for lamination of the hippocampus but not the neocortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2002

Corbo Joseph C, Deuel Thomas A, Long Jeffrey M, LaPorte Patricia, Tsai Elena, Wynshaw-Boris Anthony, Walsh Christopher A

Abstract excerpt

Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical and hippocampal development in humans. Mutations in the X-linked human DCX gene cause gross neocortical disorganization (lissencephaly or "smooth brain") in hemizygous males, whereas heterozygous females show a mosaic phenotype with a normal cortex as well as a second band of misplaced (heterotopic) neurons beneath the...

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Identifiers

PMID: 12196578
PMCID: PMC6757990

Genes

DCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Doublecortin is required in mice for lamination of the hippocampus but not the neocortex.PMID 12196578Read ↗

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Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells.Semantic proximity Read ↗

<i>DCX</i> knockout ferret reveals a neurogenic mechanism in cortical developmentSemantic proximity Read ↗

Heterotopia Formation in Rat but Not Mouse Neocortex after RNA Interference Knockdown of DCXSemantic proximity Read ↗

Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.Semantic proximity Read ↗

Doublecortin mutations cluster in evolutionarily conserved functional domains.Semantic proximity Read ↗

Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons.Semantic proximity Read ↗

Characterization of the HeCo Mutant Mouse: A New Model of Subcortical Band Heterotopia Associated with Seizures and Behavioral DeficitsSemantic proximity Read ↗

Doublecortin restricts neuronal branching by regulating tubulin polyglutamylationSemantic proximity Read ↗

Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.Semantic proximity Read ↗

Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis.Semantic proximity Read ↗

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