Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.

Nature cell biology - 1 May 2018

Choi Jaewoo, Lee Kyutae, Ingvarsdottir Kristin, Bonasio Roberto, Saraf Anita, Florens Laurence, Washburn Michael P, Tadros Saber, Green Michael R, Busino Luca

Abstract excerpt

Kelch-like protein 6 (KLHL6) is an uncharacterized gene mutated in diffuse large B-cell lymphoma (DLBCL). Here we report that KLHL6 assembles with cullin3 to form a functional cullin-RING ubiquitin ligase. Mutations in KLHL6 inhibit its ligase activity by disrupting the interaction with cullin3. Loss of KLHL6 favours DLBCL growth and survival both in vitro and in xenograft models. We further established that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphoma, Large B-Cell, Diffuse
Share to Mice, Inbred NOD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Proteolysis

Share to Receptors, Antigen, B-Cell

Share to RNA Stability

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 29695787
DOI: 10.1038/s41556-018-0084-5
PMCID: PMC5926793

Genes

KLHL6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.PMID 29695787Read ↗

Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma.Semantic proximity Read ↗

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.Semantic proximity Read ↗

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance.Semantic proximity Read ↗

Expression, purification, and microscopic characterization of the tumor suppressor KLHL6.Semantic proximity Read ↗

A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213–UBE2J2 complexSemantic proximity Read ↗

KLHL9 acts as a KSHV vBcl-2-interacting host factor that supports lytic replicationSemantic proximity Read ↗

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative diseaseSemantic proximity Read ↗

BCL6 represses NFκB activity in diffuse large B‐cell lymphomasSemantic proximity Read ↗

From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in DiseaseSemantic proximity Read ↗

Cullin-RING Ligase 5: Functional characterization and its role in human cancersSemantic proximity Read ↗

CRL Ubiquitin Ligases and DNA Damage ResponseSemantic proximity Read ↗

Characteristics of the Kelch domain containing ( KLHDC ) subfamily and relationships with diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.