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Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

24 Jul 2020

Abstract excerpt

Severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) has caused over 13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate. Laboratory mice have been the stalwart of therapeutic and vaccine development; however, they do not support infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry receptor angiotensin-converting enzyme 2...

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PMID: 32750141
DOI: 10.1084/jem.20201241

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