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Feed-forward metabotropic signaling by Cav1 Ca <sup>2+</sup> channels supports pacemaking in pedunculopontine cholinergic neurons

2023-08-07

Abstract excerpt

Like a handful of other neuronal types in the brain, cholinergic neurons (CNs) in the pedunculopontine nucleus (PPN) are lost in the course of Parkinson’s disease (PD). Why this is the case is unknown. One neuronal trait implicated in PD selective neuronal vulnerability is the engagement of feed-forward stimulation of mitochondrial oxidative phosphorylation (OXPHOS) to meet high bioenergetic demand, leading to sus...

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Literature Corpus work
bf4c08ce-99b4-57a3-a70c-d4814907fe70
DOI
10.1101/2023.08.05.552108
Open publication

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Feed-forward metabotropic signaling by Cav1 Ca <sup>2+</sup> channels supports pacemaking in pedunculopontine cholinergic neuronsDOI 10.1101/2023.08.05.552108
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