Article

From Drug-Induced Network Hyperexcitability to Neuronal ATP Failure and Mitochondrial Dysfunction: A Cross-Tier Framework and Experimental Roadmap

2025-10-23

Abstract excerpt

A growing body of experimental evidence indicates that brief or sustained network hyperexcitability can precipitate and amplify mitochondrial pathology by converting transient metabolic stress into enduring neuronal and circuit dysfunction. We synthesize this evidence into an operational integrative model: (1) elevated firing increases Na⁺/K⁺-ATPase and other pump workload, sharply elevating local ATP demand; (2)...

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Literature Corpus work: 3cbc0df2-c673-52ac-a81f-774fc8fb5022
DOI: 10.20944/preprints202510.1835.v1

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