Article

A mitochondrial tipping point couples early hyperexcitability to late-stage failure in patient-derived ALS motor neurons

2026-03-23

Abstract excerpt

<h4>SUMMARY</h4> Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by profound alterations in energy metabolism and progressive degeneration of MNs. Evidence from patients and model systems point to MN hyperexcitability as an early hallmark of ALS. How altered electrical activity intersects with energy metabolism, however, remains largely unexplored. To directly examine this relatio...

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Literature Corpus work: 9b423154-b378-52d7-b696-86f5b59954b6
DOI: 10.64898/2026.03.20.713134

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