Article

Dysregulation of energy metabolism and calcium homeostasis in iPSC-derived neurons carrying Presenilin-1 M146L gene mutation

2025-09-14

Abstract excerpt

Impaired cellular activities, particularly in highly active cells such as neurons, are primarily supported by metabolic abnormalities and failures in Ca²⁺ homeostasis. Here, we provide an integrative analysis of human iPSC-derived neurons (iNs) carrying the Presenilin-1 M146L gene mutation (PS1 M146L ) and control cells (PS1 control ). PS1 M146L iNs exhibited abnormal Ca²⁺ dynamics, a significant increase in ke...

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Literature Corpus work: f8b3b0d8-386f-5e20-8774-6d82aed0b1e9
DOI: 10.1101/2025.09.08.674945

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