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Article

Physiological phenotype and vulnerability in Parkinson's disease.

Cold Spring Harbor perspectives in medicine - 1 Jul 2012

Surmeier D James, Guzman Jaime N, Sanchez Javier, Schumacker Paul T

Abstract excerpt

This review will focus on the principles underlying the hypothesis that neuronal physiological phenotype-how a neuron generates and regulates action potentials-makes a significant contribution to its vulnerability in Parkinson's disease (PD) and aging. A cornerstone of this hypothesis is that the maintenance of ionic gradients underlying excitability can pose a significant energetic burden for neurons,...

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Identifiers

PMID: 22762023
DOI: 10.1101/cshperspect.a009290
PMCID: PMC3385938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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