Article

Chemogenetic restoration of autonomous subthalamic nucleus activity ameliorates Parkinsonian motor dysfunction

2018-08-16

Abstract excerpt

<h4>Highlights</h4> decorrelating autonomous STN activity was downregulated in both toxin and genetic models of PD elevation of D2-striatal projection neuron transmission was sufficient for downregulation downregulation was dependent on activation of STN NMDA receptors and KATP channels chemogenetic restoration of autonomous spiking reduced synaptic patterning of STN neurons and PD motor dysfunction <h4>eToC<...

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Literature Corpus work: e2e33f80-637e-550a-bf7a-a8bcc2fc7b11
DOI: 10.1101/385443

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