Article

Whole-genome sequencing of mixed OCD–schizophrenia pedigrees characterizes shared and divergent rare-variant architectures

2026-03-18

Abstract excerpt

<title>Abstract</title> <p>Psychiatric disorders often co-occur and share liability, yet why distinct diagnoses arise under a largely shared familial genetic background remains poorly understood. We assembled 21 Han Chinese mixed pedigrees co-ascertained for obsessive–compulsive disorder (OCD) and schizophrenia (SCZ) (21 OCD, 21 SCZ, and 38 unaffected first-degree relatives) and performed deep (60×) whole-genome...

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Literature Corpus work: 6beb24a1-88df-5487-ba5d-276e661d35c7
DOI: 10.21203/rs.3.rs-8943594/v1

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