Article

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

2025-04-07

Abstract excerpt

Reprogramming of aged donor tissue cells into induced pluripotent stem cells (A-iPSC) preserved the epigenetic memory of aged-donor tissue, defined as genomic instability and poor tissue differentiation in our previous study. The unbalanced expression of RNA exosome subunits affects the RNA degradation complex function and is associated with geriatric diseases including premature aging and cancer progression. We h...

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Literature Corpus work: bf076c02-b6e3-5139-963e-a0c1352b5dd0
DOI: 10.1101/2025.04.04.647279

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