Article

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

2018-03-31

Abstract excerpt

<h4>Summary</h4> Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the promise for tissue replacement to counter age-related decline. However, attempts to realise in vivo iPSC have invariably resulted in the formation of teratomas. Partial reprogramming in prematurely aged mice has shown promising results in alleviating age-related symptoms without teratoma formation. Does...

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Literature Corpus work: 3cdfe6fb-f814-5e24-ae2b-8ab70048588b
DOI: 10.1101/292680

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