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Article

RVD2: an ultra-sensitive variant detection model for low-depth heterogeneous next-generation sequencing data.

Bioinformatics (Oxford, England) - 1 Sept 2015

He Yuting, Zhang Fan, Flaherty Patrick

Abstract excerpt

MOTIVATION: Next-generation sequencing technology is increasingly being used for clinical diagnostic tests. Clinical samples are often genomically heterogeneous due to low sample purity or the presence of genetic subpopulations. Therefore, a variant calling algorithm for calling low-frequency polymorphisms in heterogeneous samples is needed. RESULTS: We present a novel variant calling algorithm that uses a...

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Identifiers

PMID: 25931517
DOI: 10.1093/bioinformatics/btv275
PMCID: PMC4547613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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