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Article

Calling small variants using universality with Bayes-factor-adjusted odds ratios.

Briefings in bioinformatics - 17 Jan 2022

Zhao Xiaofei, Hu Allison C, Wang Sizhen, Wang Xiaoyue

Abstract excerpt

The application of next-generation sequencing in research and particularly in clinical routine requires highly accurate variant calling. Here we describe UVC, a method for calling small variants of germline or somatic origin. By unifying opposite assumptions with sublation, we discovered the following two empirical laws to improve variant calling: allele fraction at high sequencing depth is inversely proportional...

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PMID: 34791010
DOI: 10.1093/bib/bbab458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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