Article

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

2021-12-14

Abstract excerpt

Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics. MicroRNAs are important regulators of gene expression, and their activity can be altered by oncogenic mutations. However, it is unknown how distinct combinations of CRC-risk mutation...

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Literature Corpus work: bee0d813-7bf8-546b-a96f-93cda62be6e7
DOI: 10.1101/2021.12.13.472432

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