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Article

Human Colorectal Cancer from the Perspective of Mouse Models

11 Oct 2019

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease that includes both hereditary and sporadic types of tumors. Tumor initiation and growth is driven by mutational or epigenetic changes that alter the function or expression of multiple genes. The genes predominantly encode components of various intracellular signaling cascades. In this review, we present mouse intestinal cancer models that include alterations in...

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PMID: 31614493
DOI: 10.3390/genes10100788

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