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Article

Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival.

BMC genomics - 1 Dec 2022

Villanueva Jonathan W, Kwong Lawrence, Han Teng, Martinez Salvador Alonso, Shanahan Michael T, Kanke Matt, Dow Lukas E, Danko Charles G, Sethupathy Praveen

Abstract excerpt

Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics. MicroRNAs are important regulators of gene expression, and their activity can be altered by oncogenic mutations. However, it is unknown how distinct combinations of CRC-risk...

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PMID: 36457077
DOI: 10.1186/s12864-022-09018-1
PMCID: PMC9716731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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