Article

Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s disease

2025-09-30

Abstract excerpt

Pituitary adenomas constitute up to 20% of primary brain tumors, yet somatic mutations are only found in 15% of pituitary adenomas. Epigenomic dysregulation has been proposed as a tumorigenic mechanism in pituitary adenomas causing Cushing’s disease (CD). We created paired datasets of human CD adenomas and en-route margin adult human pituitary glands and assayed their chromatin accessibility, DNA methylation, tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9f3fa3f-726c-56d7-868f-01975964ac67
DOI: 10.1101/2025.09.28.679056

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s diseaseDOI 10.1101/2025.09.28.679056Read

Epigenetic reactivation of a neurodevelopmental phosphoprotein program in pituitary adenomasSemantic proximity Read

Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomasSemantic proximity Read

Pituitary adenomas evade apoptosis via noxa deregulation in Cushing’s diseaseSemantic proximity Read

Rules for PP2A-controlled phosphosignalling and drug responsesSemantic proximity Read

The hallmarks of cancer… in pituitary tumors?Semantic proximity Read

Transcriptome and methylome analysis reveals three cellular origins of pituitary tumorsSemantic proximity Read

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.Semantic proximity Read

The Epigenomics of Pituitary AdenomaSemantic proximity Read

From Genes to Therapy: Pituitary Adenomas in the Era of Precision MedicineSemantic proximity Read

Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndromeSemantic proximity Read

A review of multiomics platforms in pituitary adenoma pathogenesisSemantic proximity Read

<i>O</i> -GlcNAcylation is essential for rapid <i>Pomc</i> expression and cell proliferation in corticotropic tumor cellsSemantic proximity Read