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Article

Structural insights into mis-regulation of protein kinase A in human tumors.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2015

Cheung Jonah, Ginter Christopher, Cassidy Michael, Franklin Matthew C, Rudolph Michael J, Robine Nicolas, Darnell Robert B, Hendrickson Wayne A

Abstract excerpt

The extensively studied cAMP-dependent protein kinase A (PKA) is involved in the regulation of critical cell processes, including metabolism, gene expression, and cell proliferation; consequentially, mis-regulation of PKA signaling is implicated in tumorigenesis. Recent genomic studies have identified recurrent mutations in the catalytic subunit of PKA in tumors associated with Cushing's syndrome, a kidney...

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Identifiers

PMID: 25605907
DOI: 10.1073/pnas.1424206112
PMCID: PMC4321305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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