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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

2018-05-25

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multi-plex data from patient tissue, three-dimensional co-culturing in vitro assays, and orthotopic murine models, we identified Netrin G1 (NetG1) as a promoter of PDAC tumorigenesis. NetG1 + cancer-associated fibroblasts (CAFs) supporte...

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Identifiers and source

Literature Corpus work
bec870c6-4860-5d94-96d9-fe9b74cde718
DOI
10.1101/330209
Open publication

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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppressionDOI 10.1101/330209
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