Article

Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine

2021-11-30

Abstract excerpt

<h4>ABSTRACT</h4> The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding initial triggers of immunosuppression during the process of pancreatic tumorigenesis would aid in establishing novel targets for effective prevention and therapy. Here, we interrogate the differential molecular mechanisms dependent on cell of origin and path...

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Literature Corpus work: 19b13a16-5fec-5499-a2b3-d92d50ede80a
DOI: 10.1101/2021.11.29.470415

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