Article

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1

2025-07-26

Abstract excerpt

Nerves have been shown to regulate cancer progression. However, a clear demonstration of a role for axon guidance molecules in pancreatic tumorigenesis, innervation, and metastasis has been lacking. Using murine Kras G12D -mutant pancreatic organoids, we screened axon guidance molecules by qRT-PCR, identified Ntn1 upregulation, and then verified its in vivo upregulation during pancreatic tumorigenesis in human...

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Literature Corpus work: 360b8c12-7bff-5211-a128-4dfb893fcab7
DOI: 10.1101/2025.07.22.666009

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