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NetrinG1 <sup>+</sup> cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

2021-11-24

Abstract excerpt

It is projected that, in 5 years, pancreatic cancer will become the second deadliest cancer in the United States. A unique aspect of pancreatic ductal adenocarcinoma (PDAC) is its stroma; rich in cancer-associated fibroblasts (CAFs) and a dense CAF-generated extracellular matrix (ECM). This fibrous stroma, known as desmoplasia, causes the collapse of local blood vessels rendering a nutrient-deprived milieu. Hence,...

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Literature Corpus work
4dcd2ce4-37b2-5726-a6ad-1f3d726625a5
DOI
10.1101/2021.11.21.469456
Open publication

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NetrinG1 <sup>+</sup> cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stressDOI 10.1101/2021.11.21.469456
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