Article

Mammary-specific ectopic expression of mutant human GATA3 did not potentiate medroxyprogesterone acetate-driven mouse mammary tumorigenesis

2023-01-03

Abstract excerpt

<h4>ABSTRACT</h4> GATA3 is somatically mutated in approximately 15% of estrogen receptor positive human breast tumors, however the mechanism(s) by which these alterations contribute to tumorigenesis are unclear. The observed patterns of mutations suggest a strong selective pressure to mutate a single allele of GATA3 in a manner favoring retention of the first of two zinc finger domains. The non-mutated GATA3 alle...

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Literature Corpus work: bec704db-d4a8-5fd6-8c9e-7b47d0f86634
DOI: 10.1101/2023.01.03.522644

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