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Article

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.

Oncogene - 2 Jan 2015

Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg L E, Sites E, Sandy A, Trimboli A, Fernandez S A, Eng C, Shapiro C, Leone G

Abstract excerpt

Previous studies have demonstrated that cyclin D1, an upstream regulator of the Rb/E2F pathway, is an essential component of the ErbB2/Ras (but not the Wnt/Myc) oncogenic pathway in the mammary epithelium. However, the role of specific E2fs for ErbB2/Ras-mediated mammary tumorigenesis remains unk...

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Share to E2F1 Transcription Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Mammary Neoplasms, Experimental

Share to Phosphorylation

Share to Proto-Oncogene Proteins c-myc

Share to Receptor, ErbB-2

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Identifiers

PMID: 24276244
DOI: 10.1038/onc.2013.511
PMCID: PMC4032808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24276244-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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