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Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice.

Reproduction, fertility, and development - 1 May 2020

Atashgaran Vahid, Dasari Pallave, Hodson Leigh J, Evdokiou Andreas, Barry Simon C, Ingman Wendy V

Abstract excerpt

Female mice heterozygous for a genetic mutation in transcription factor forkhead box p3 (Foxp3) spontaneously develop mammary cancers; however, the underlying mechanism is not well understood. We hypothesised that increased cancer susceptibility is associated with an underlying perturbation in mammary gland development. The role of Foxp3 in mammary ductal morphogenesis was investigated in heterozygous Foxp3Sf/+...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32389178
DOI: 10.1071/RD19378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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