Distinct spatial immune microenvironment features of different EGFR mutation subtypes in early-stage lung adenocarcinoma.

doi:10.1016/j.lungcan.2026.109562

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Article

Distinct spatial immune microenvironment features of different EGFR mutation subtypes in early-stage lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2026

Dai Kongxu, Cheng Sida, Wu Cong, Wang Yulong, Liu Xu, Li Xinrui, Zhao Yaxing, Sheng Jianpeng, Li Yun, Yang Fan, Chen Kezhong, Li Hao

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are common in lung adenocarcinoma (LUAD), yet their influence on the spatial tumor immune microenvironment (TIME) in early-stage disease remains unclear. We characterized the spatial TIME in 144 treatment-naïve, early-stage LUADs using integrated genomic sequencing and multiplex immunohistochemistry (mIHC). Although EGFR-mutant tumors overall displayed reduced...

Read the complete abstract on PubMed

Topics

Humans
Tumor Microenvironment
Mutation
ErbB Receptors
Lung Neoplasms
Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neoplasm Staging

Female

Male

CD8-Positive T-Lymphocytes

Middle Aged

Aged

Lymphocytes, Tumor-Infiltrating

Source

Open in PubMed

Identifiers

PMID: 42612510
DOI: 10.1016/j.lungcan.2026.109562

Genes

EGFR
TP53

Variants

Provenance

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