Article

Improved gene targeting in vivo using EoHR, a small molecule inhibitor of 53BP1

2024-06-01

Abstract excerpt

Precise genome editing by programmable nucleases such as Cas9 has revolutionised medical research by enabling the creation of gene-edited or knock-in mouse models of disease. However, a major limitation of the approach is the inefficient process of homology driven recombination (HDR) from an exogenous DNA repair template. This is because error-prone, 53BP1-dependent non-homologous end joining (NHEJ) predominates a...

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Literature Corpus work: bea19e2f-5eac-51c7-af13-760ab0a5a323
DOI: 10.1101/2024.05.30.596757

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