Article

Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

2023-11-16

Abstract excerpt

Homology Directed Repair (HDR) enables precise genome editing and holds great promise in the gene therapy field. However, the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ). In this study, we demonstrate the development of a functional, pooled screening platform utilizing an HDR-b...

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Literature Corpus work: 1bd04ad2-7b45-5236-bd35-6ce907589756
DOI: 10.1101/2023.11.16.567426

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