Article

A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale

2021-07-22

Abstract excerpt

Constraint-based (CB) metabolic models provide a mathematical framework and scaffold for in silico cell metabolism analysis and manipulation. In the past decade, significant efforts have been done to model human metabolism, enabled by the increased availability of multi-omics datasets and curated genome-scale reconstructions, as well as the development of several algorithms for context-specific model (CSM) recons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be9c653b-6206-5dba-82de-a2fec864bf5d
DOI: 10.1101/2021.07.22.453372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scaleDOI 10.1101/2021.07.22.453372Read

A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale.Semantic proximity Read

A new genome-scale model enables prediction of cancer metabolic dependenciesSemantic proximity Read

Using the reconstructed genome-scale human metabolic network to study physiology and pathology.Semantic proximity Read

Transcriptome-Driven Constraint-Based Modelling Reveals Metabolic Targets for Ovarian CancerSemantic proximity Read

On the inconsistent treatment of gene-protein-reaction rules in context-specific metabolic modelsSemantic proximity Read

Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell LinesSemantic proximity Read

INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulationSemantic proximity Read

Curating MitoCore: A Standardized Small-Scale Human Metabolic Model as Platform for Proteomics Integration and Disease ModelingSemantic proximity Read

Systematic Analysis of Human Tissue- and Cell-Specific Metabolic Models Identifies High-Sugar, High-Fat Diet–Induced Liver DysregulationSemantic proximity Read

Towards personalized genome-scale modeling of inborn errors of metabolism for systems medicine applications.Semantic proximity Read

Constraint-based modeling predicts metabolic signatures of low- and high-grade serous ovarian cancerSemantic proximity Read

MitoCore: A curated constraint-based model for simulating human central metabolismSemantic proximity Read