Article

Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell Lines

2026-06-03

Abstract excerpt

Genome-scale metabolic models (M-models) provide mechanistic insight into intracellular metabolism by simulating fluxes subject to nutrient and energy resource constraints. However, they cannot account for a major component of resource allocation, since they do not explicitly account for the cost of producing and maintaining enzymes. Genome-scale models of metabolism and gene expression (ME-Models) address this by...

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Literature Corpus work: 092916b3-4be6-5a50-a996-229ef66d7e36
DOI: 10.64898/2026.05.30.728988

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